As a supplier of 222nm UV technology, I am often asked about the types of microorganisms that this specific wavelength of ultraviolet light can effectively kill. In this blog, I will delve into the scientific aspects of 222nm UV and its efficacy against various microorganisms, which is crucial for understanding its applications in disinfection and public health. 222nm UV

Understanding 222nm UV
222nm UV, also known as far – ultraviolet C (far – UVC), is a part of the ultraviolet spectrum. Unlike traditional UVC light (200 – 280nm), which can be harmful to human skin and eyes, 222nm UV has a unique property. It is absorbed by the outer layer of human skin and the tear layer of the eyes, preventing it from reaching living cells and causing damage. This characteristic makes it a promising candidate for continuous, in – use disinfection in occupied spaces.
Bacteria
Bacteria are single – celled microorganisms that can cause a wide range of diseases. Many common bacteria are susceptible to 222nm UV.
Escherichia coli (E. coli)
E. coli is a well – known bacterium that can cause food poisoning, urinary tract infections, and other illnesses. Studies have shown that 222nm UV can effectively inactivate E. coli. The UV light damages the DNA and RNA of the bacteria, preventing them from replicating. In laboratory settings, exposure to 222nm UV for a relatively short period can significantly reduce the number of viable E. coli cells.
Staphylococcus aureus
Staphylococcus aureus is a bacterium that can cause skin infections, pneumonia, and other serious diseases. It is often found in hospitals and other healthcare settings. 222nm UV has been demonstrated to be effective against S. aureus. The far – UVC light penetrates the cell wall of the bacteria and disrupts their genetic material, leading to cell death.
Pseudomonas aeruginosa
Pseudomonas aeruginosa is a gram – negative bacterium that can cause infections in patients with weakened immune systems. It is known for its resistance to many antibiotics. However, 222nm UV can still inactivate this bacterium. The UV light targets the essential components of the bacterial cell, such as proteins and nucleic acids, and breaks them down, rendering the bacteria non – viable.
Viruses
Viruses are much smaller than bacteria and consist of genetic material (DNA or RNA) surrounded by a protein coat. 222nm UV can also be effective against a variety of viruses.
Influenza virus
Influenza, or the flu, is a highly contagious viral disease. 222nm UV has been shown to be able to inactivate influenza viruses. The UV light damages the viral genetic material, preventing the virus from infecting host cells. In a study, continuous exposure to 222nm UV in a room significantly reduced the concentration of airborne influenza viruses, which could potentially reduce the spread of the flu.
SARS – CoV – 2
The virus responsible for the COVID – 19 pandemic, SARS – CoV – 2, has also been the subject of research regarding 222nm UV. Laboratory experiments have demonstrated that 222nm UV can effectively inactivate SARS – CoV – 2. The far – UVC light disrupts the virus’s spike proteins and genetic material, making it unable to infect human cells. This makes 222nm UV a valuable tool for disinfection in public spaces, such as hospitals, schools, and offices, to reduce the risk of virus transmission.
Norovirus
Norovirus is a common cause of gastroenteritis, which is characterized by vomiting and diarrhea. It is highly contagious and can spread easily in crowded places. 222nm UV has the potential to inactivate norovirus. By damaging the virus’s genetic material, it can prevent the virus from replicating and causing infection.
Fungi
Fungi are eukaryotic microorganisms that can cause various infections, such as athlete’s foot, ringworm, and fungal pneumonia.
Candida albicans
Candida albicans is a yeast – like fungus that can cause infections in the mouth, throat, and genital area. 222nm UV can be effective against Candida albicans. The UV light damages the fungal cell wall and genetic material, leading to cell death. In a study, exposure to 222nm UV reduced the viability of Candida albicans colonies.
Aspergillus fumigatus
Aspergillus fumigatus is a mold that can cause serious lung infections, especially in immunocompromised patients. 222nm UV has been shown to have an inhibitory effect on Aspergillus fumigatus. The far – UVC light disrupts the fungal growth and reproduction processes by damaging the DNA and proteins within the fungal cells.
Mechanism of Action
The mechanism by which 222nm UV kills microorganisms is based on its ability to damage the genetic material (DNA and RNA) of the cells. When 222nm UV is absorbed by the nucleic acids in the microorganisms, it causes the formation of thymine dimers. Thymine dimers are abnormal structures that prevent the normal replication and transcription of DNA and RNA. As a result, the microorganisms are unable to reproduce and eventually die.
Applications in Different Settings
The ability of 222nm UV to kill a wide range of microorganisms makes it suitable for various applications.
Healthcare settings
In hospitals and clinics, 222nm UV can be used for continuous disinfection of patient rooms, operating theaters, and waiting areas. It can help reduce the risk of healthcare – associated infections by inactivating bacteria, viruses, and fungi that may be present in the air and on surfaces.
Public transportation
Buses, trains, and airplanes are often crowded spaces where the spread of infectious diseases can occur easily. Installing 222nm UV disinfection systems in these vehicles can help reduce the concentration of airborne microorganisms and protect passengers.
Schools and universities
In educational institutions, 222nm UV can be used to disinfect classrooms, libraries, and other common areas. This can help prevent the spread of diseases among students and staff, especially during flu seasons.
Conclusion

In conclusion, 222nm UV is a powerful tool for disinfection, capable of killing a wide range of microorganisms, including bacteria, viruses, and fungi. Its unique property of being safe for human exposure while effectively inactivating pathogens makes it an ideal solution for continuous disinfection in occupied spaces.
126nm UV If you are interested in learning more about our 222nm UV products or have any questions regarding their applications, we encourage you to reach out to us. We are ready to provide you with detailed information and support to meet your disinfection needs.
References
- Kowalski, W. J. (2009). Ultraviolet Germicidal Irradiation Handbook: UVGI for Air and Surface Disinfection. Springer.
- Buonanno, G., et al. (2020). In – room far – UVC exposure limits airborne influenza virus infectivity. Scientific Reports, 10(1), 1 – 7.
- Setlow, R. B. (2001). DNA damage and repair in ultraviolet – irradiated bacteria. Radiation Research, 155(1), 113 – 121.
Shenzhen Lights Technology Co., Ltd
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